Acidosis - A Medical Dictionary, Bibliography, and Annotated by Icon Health Publications

By Icon Health Publications

This can be a 3-in-1 reference ebook. It supplies an entire clinical dictionary masking thousands of phrases and expressions with regards to acidosis. It additionally offers large lists of bibliographic citations. ultimately, it offers info to clients on how you can replace their wisdom utilizing a number of web assets. The booklet is designed for physicians, clinical scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to familiarize yourself with learn devoted to acidosis. in the event that your time is efficacious, this booklet is for you. First, you won't waste time looking the web whereas lacking loads of correct info. moment, the ebook additionally saves you time indexing and defining entries. ultimately, you won't waste time and cash printing hundreds and hundreds of web content.

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Additional resources for Acidosis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

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Successful completion of this project will enhance our understanding of the mechanisms responsible for regulating H+/base transporters. ; Professor; Beth Israel Deaconess Medical Center St 1005 Boston, Ma 02215 Timing: Fiscal Year 2002; Project Start 15-JAN-1991; Project End 31-MAR-2003 Summary: (Adapted from the Applicant's Abstract): The AE anion exchanger gene family encodes complex polytopic transmembrane polypeptides that contribute to regulation of intracellular pH (pHi), cell [Cl-], and cell volume through their mediation of electroneutral Cl-/HCO3- exchange.

Specifically, we will isolate, clone and sequence cDNAs encoding the transporter, determine anion specificity and transport modes by functional expression in Xenopus oocytes; general specific antibodies, and determine cell and membrane sites of expression; determine whether different isoforms of the transporter exist; examine structure-function relationships by use of chimeric constructs; and estimate the contribution of the transporter to integrated tubule function in microperfusion studies in mice with targeted disruption of the transporter gene.

Enzymes under investigation include hydroxymethylglutaryl-CoA (HMG-CoA) synthase and HMG-CoA lyase will be investigated to elucidate structure/function correlations that account for the catalytic activity and regulatory properties. For each of these, the investigators have developed recombinant proteins and initiated extensive steps in characterizing these proteins. For HMG-CoA synthase, site directed mutagenesis has implicated several active site amino aids in catalysis. Several aims address functional assignments for these and any other residues identified as important to the reaction chemistry.

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