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Extra info for AID for Immunoglobulin Diversity
And Schatz, D. G. (2005). Histone modifications associated with somatic hypermutation. Immunity 23, 101–110. Okazaki, I. , and Honjo, T. (2002). The AID enzyme induces class switch recombination in fibroblasts. Nature 416, 340–345. Okazaki, I. , and Honjo, T. (2003). Constitutive expression of AID leads to tumorigenesis. J. Exp. Med. 197, 1173–1181. , Nagelhus, T. , and Krokan, H. E. (1998). Nuclear and mitochondrial splice forms of human uracil‐DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectively.
J. Biol. Chem. 273, 8009–8016. , Scharff, M. , and Goodman, M. F. (2003). Activation‐induced cytidine deaminase deaminates deoxycytidine on single‐stranded DNA but requires the action of RNase. Proc. Natl. Acad. Sci. USA 100, 4102–4107. , and Goodman, M. F. (2004). Biochemical analysis of hypermutational targeting by wild type and mutant activation‐induced cytidine deaminase. J. Biol. Chem. 279, 51612–51621. 30 M A S A M I C H I M U R A M AT S U E T A L . Brar, S. , and Diaz, M. (2004). Activation‐induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks.
35, 397–404. Rush, J. , Fugmann, S. , and Schatz, D. G. (2004). Staggered AID‐dependent DNA double strand breaks are the predominant DNA lesions targeted to Sm in Ig class switch recombination. Int. Immunol. 16, 549–557. , Schreier, M. , Eugster, H. , and Quesniaux, V. F. (1997). Lack of type 2 T cell‐independent B cell responses and defect in isotype switching in TNF‐lymphotoxin a‐deficient mice. J. Immunol. 158, 2126–2133. , and Pearl, L. H. (1995). Nucleotide mimicry in the crystal structure of the uracil‐DNA glycosylase‐uracil glycosylase inhibitor protein complex.