AID for Immunoglobulin Diversity by Frederick W. Alt

By Frederick W. Alt

Advances in Immunology, an extended confirmed and hugely revered serial, offers present advancements in addition to entire reports in immunology. Articles handle the wide variety of themes that contain immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and scientific modalities. Edited and authored by means of the main scientists within the box, every one quantity offers up to date info and instructions for destiny examine.

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And Schatz, D. G. (2005). Histone modifications associated with somatic hypermutation. Immunity 23, 101–110. Okazaki, I. , and Honjo, T. (2002). The AID enzyme induces class switch recombination in fibroblasts. Nature 416, 340–345. Okazaki, I. , and Honjo, T. (2003). Constitutive expression of AID leads to tumorigenesis. J. Exp. Med. 197, 1173–1181. , Nagelhus, T. , and Krokan, H. E. (1998). Nuclear and mitochondrial splice forms of human uracil‐DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectively.

J. Biol. Chem. 273, 8009–8016. , Scharff, M. , and Goodman, M. F. (2003). Activation‐induced cytidine deaminase deaminates deoxycytidine on single‐stranded DNA but requires the action of RNase. Proc. Natl. Acad. Sci. USA 100, 4102–4107. , and Goodman, M. F. (2004). Biochemical analysis of hypermutational targeting by wild type and mutant activation‐induced cytidine deaminase. J. Biol. Chem. 279, 51612–51621. 30 M A S A M I C H I M U R A M AT S U E T A L . Brar, S. , and Diaz, M. (2004). Activation‐induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks.

35, 397–404. Rush, J. , Fugmann, S. , and Schatz, D. G. (2004). Staggered AID‐dependent DNA double strand breaks are the predominant DNA lesions targeted to Sm in Ig class switch recombination. Int. Immunol. 16, 549–557. , Schreier, M. , Eugster, H. , and Quesniaux, V. F. (1997). Lack of type 2 T cell‐independent B cell responses and defect in isotype switching in TNF‐lymphotoxin a‐deficient mice. J. Immunol. 158, 2126–2133. , and Pearl, L. H. (1995). Nucleotide mimicry in the crystal structure of the uracil‐DNA glycosylase‐uracil glycosylase inhibitor protein complex.

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