AMP-activated Protein Kinase by Mario D. Cordero, Benoit Viollet

By Mario D. Cordero, Benoit Viollet

AMPK has emerged as an immense integrator of signs that keep watch over strength stability in the course of the law of a number of biochemical pathways in eukaryotes.

This ebook specializes in the consequences of AMPK as a grasp metabolic regulator in illnesses, together with new equipment and animal versions. The contributions are written through prime specialists within the box and provides an intensive assessment of the present wisdom of AMPK biology and the position of AMPK in wellbeing and fitness and illness.

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Chem Biol 21:1–9 Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC (2004) The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci 101:3329–3335 Steinberg GR, Kemp BE (2009) AMPK in health and disease. Physiol Rev 89:1025–1078 Suter M, Riek U, Tuerk R, Schlattner U, Wallimann T, Neumann D (2006) Dissecting the role of 50 -AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase.

24 25 26 28 29 29 30 30 30 31 33 34 34 37 Abstract This chapter summarizes AMPK function in the regulation of substrate and energy metabolism with the main emphasis on carbohydrate and lipid metabolism, protein turnover, mitochondrial biogenesis, and whole-body energy homeostasis. AMPK acts as whole-body energy sensor and integrates different signaling pathway to meet both cellular and body energy requirements while inhibiting energy-consuming processes but also activating energy-producing ones.

1 Fatty Acid Uptake . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Lipid Synthesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Acetyl-CoA Carboxylase and Fatty Acid Oxidation . . . . . . . . . . . . . . . 4 AMPK, Insulin Sensitivity, and Whole-Body Energy Balance . . . . . . . . . . . . .

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