By Ricardo Azziz
The sector of androgen extra problems has complicated considerably because the unique ebook of this booklet. The Androgen extra Society (AES) used to be based to assemble investigators within the box. a greater realizing of the screening, development, and molecular genetics of nonclassic adrenal hyperplasia (NCAH) has stronger the scientific care and diagnostic accuracy of those sufferers. New standards for the analysis of the polycystic ovary syndrome (PCOS) have been proposed in Rotterdam, standards that experience ended in controversy and, with a bit of luck, initiation of latest reviews. The organization of insulin resistance with PCOS has been bolstered, and the function of metformin in tre- ing the infertility of the PCOS has been established. dangers for diabetes and, extra cont- versially, heart problems in ladies with PCOS have got significant research. Our realizing of the epidemiology and financial influence of those issues has improved, emphasizing their serious significance. those are yet a couple of highlights of the way the terrain has replaced in a comparatively short time period. based on those advances, the name of this publication has been revised to mirror the turning out to be significance of PCOS because the so much customary androgen extra sickness in ladies, and arguably, because the person who may need the main severe antagonistic results for normal well-being. There are fewer chapters to supply a extra concentrated elucidation of the realm. a number of chapters have been penned via new (and younger) authors who're undertaking state-of-the-art examine within the box.
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Extra resources for Androgen excess disorders in women : polycystic ovary syndrome and other disorders
STEROID SULFOTRANSFERASE AND SULFATASE Steroid sulfates may be synthesized directly from cholesterol sulfate or by sulfating '5 steroids by the main sulfotransferases, SULT2A1 and SULT2B1, and the phenolic sulfotransferase SULT1E1. The addition of a sulfate group prevents the activation of '5 steroids to '4 steroids by 3E-HSD. SULT2A1, which is expressed primarily the adrenals and to a lesser degree the liver and kidney, sulfates DHEA (45). SULT2A1 is not expressed in the ovary (45), whereas SULT2B1 and SULT1E1 are widely expressed (46).
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Mol Cell Endocrinol 1993;97:135–143. 32. Geller DH, Auchus RJ, Mendonça BB, Miller WL. The genetic and functional basis of isolated 17,20-lyase deficiency. Nature Genet 1997;17:201–203. 33. Geller DH, Auchus RJ, Miller WL. P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b5. Mol Endocrinol 1999;13:167–175. 34. Pandey AV, Mellon SH, Miller WL. Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17.